There's no huge change, the main issue is prescription validity, in practice this is most important for zopiclone which is quite a popular medication.
| Tramadol | Lisdexamfetamine | Zopiclone | Zaleplon |
| Designation from 10th June 2014 | Schedule 3 (CD No Reg POM) | Schedule 2 (CD POM) | Schedule 4 (Part I) | Schedule 4 (Part I) |
| Safe Custody Regulations apply | No | Yes | No | No |
| Controlled Drug Prescription requirements* | Yes | Yes | No | No |
| Prescription valid for | 28 days | 28 days | 28 days | 28 days |
| Address of the prescriber required to be within the UK | Yes | Yes | No | No |
| EEA and Swiss prescribers can legally prescribe | No | No | Yes | Yes |
| Prescription is repeatable* | No | No | Yes | Yes |
| Emergency supply | No | No | Yes | Yes |
| Controlled drug Requisition necessary | Yes | Yes | No | No |
| Requisition to be marked by supplier | Yes | Yes | No | No |
| License required to import or export | Yes | Yes | Yes | Yes |
| Denature before disposal* | Yes | Yes | Yes | Yes |
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